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. Author manuscript; available in PMC: 2018 Oct 11.
Published in final edited form as: Chem Rev. 2017 Sep 27;117(19):12415–12474. doi: 10.1021/acs.chemrev.7b00283

Table 6.

MIC Assays of Analogsa

S. aureus E. faecalis E. faecium E. faecalis
ATCC 25923 ATCC 43300 BM 4166 ATCC BAA-2317 ATCC 51299
QC MRSA VanA VanA VanB
Vancomycin (4) 0.5 0.5 250 250 8
287 Y=S >32 >32 >32 >32 >32
288 Y=NH nd nd 0.5 0.5 nd
289 Y=H2 nd nd 31 31 nd
291 Y=O CBP 0.03 0.03 2.5 2.5 0.03
292 Y=S CBP 2 2 4 4 2
293 Y=NH CBP 0.03 0.06 0.005 0.005 0.06
294 Y=H2 CBP 0.5 0.25 0.13 0.06 0.5
295 Y=O CBP C0 nd nd 5 5 nd
296 Y=O CBP C1 nd nd 0.25 0.5 nd
297 Y=O CBP C5 nd nd 2 2 nd
298 Y=H2 CBP C1 nd nd 0.01 0.005 nd

graphic file with name nihms949912u5.jpg

a

Color code indicates approximate x-fold change in activity relative to vancomycin. When considering “greater than” results, we assume the best-case scenario if a comparison can be made.