Table 7.

Activities of Selected Analogs against QS in P. aeruginosa as % Activity at 100 μM Relative to Natural AHL Agonists and Antagonists

	PAO1	PAO-JP2				E. coli
	pyocyanin inhibition	LasR		RhlR		RhlR
		ant	ag	ant	ag	ant	ag
303	88	31	8	12	105	−110	91
304	84	15	10	−9	86	−95	81
305	83	−61	99	−40	102	−122	83
306	79	33	7	15	46	−52	79
307	67	3	7	41	48	−64	84
308	60	60	7	78	32	−47	71
309	−25	31	9	56	2	60	11
310	−38	47	5	85	−1	64	5
311	−44	60	2	92	−1	74	7
312	−49	33	7	54	2	84	1