Table 3.

Seven significant SNP-SNP interaction pairs identified in the GWIS of the T-tau/Aβ₄₂ ratio.

NO.	SNP1×SNP2	GENE	CHR	Main Effect	Interaction		Explained Variance (R Square)
				p-value	p-value	Corrected p-value	Age+Gendera	Dxb	APOEc	SNP1+SNP2d	SNP1* SNP2e
1	rs1514061×	PLXNA4*	7	3.41E-06	8.35E-10	0.0181	0.01	0.164	0.129	0.015	0.051
	rs6467419	PLXNA4*	7	0.00167353
2	rs1514061×	PLXNA4*	7	3.41E-06	1.97E-10	0.0043	0.01	0.164	0.129	0.019	0.047
	rs4453471	CDH13	16	0.00377003
3	rs7303599×	ADIPOR2*	12	7.91E-05	5.76E-11	0.0013	0.01	0.164	0.129	0.023	0.042
	rs7146454	ADSSL1*	14	0.00733134
4	rs7303599×	ADIPOR2*	12	7.91E-05	6.91E-10	0.0150	0.01	0.164	0.129	0.021	0.041
	rs167396	GSN*	9	0.00583631
5	rs1482548×	INHBA*	7	0.007007	2.95E-10	0.0064	0.01	0.164	0.129	0.015	0.038
	rs12894119	NIN*	14	0.00867969
6	rs9550406×	MTUS2*	13	0.00543688	1.49E-09	0.0324	0.01	0.164	0.129	0.010	0.034
	rs6471951	RLBP1L1	8	0.00604041
7	rs211953×	CXADR	21	0.000478713	3.03E-10	0.0066	0.01	0.164	0.129	0.024	0.031
	rs4881147	PITRM1*	10	0.0015086

The Bonferroni corrected p-values (< 0.05) and R² of the SNP*SNP interaction term are shown in bold.

^aAge+Gender: Percent of variance in T-tau/Aβ₄₂ level explained by age, gender.

^bDx: Percent of variance in T-tau/Aβ₄₂ level explained by diagnosis after accounting for age, gender.

^cAPOE: Percent of additional variance in T-tau/Aβ₄₂ level explained by the APOE genotype after accounting for age, gender and diagnosis.

^dSNP1+SNP2: Percent of additional variance in T-tau/Aβ₄₂ level explained by the combined main effect of SNP1 and SNP2 after accounting for age, gender, diagnosis, and the APOE genotype.

^eSNP1*SNP2: Percent of additional variance in T-tau/Aβ₄₂ level explained by the interaction effect of SNP1 and SNP2 after accounting for age, gender, diagnosis, APOE genotype, SNP1 and SNP2.

^*Nearest gene proximal to the SNP.