Table 1.

Clinical characteristics of subjects.

Patient	1	2	3	4	5	6	7	Average (±SD)
Sex	F	F	M	F	F	F	F
Age at RYGB (yrs)	46	35	40	28	32	37	25	35 ± 7
BMI before RYGB (kg/m2)	38	50	50	37	47	49	54	46 ± 7
Preop DM?	no	no	no	no	no	prediabetes	no
Onset of sxs (months post bypass)	12	19	6	56	100	32	asymptomatic	37.5 ± 36
Other problems	hypopara-thyroid		nausea/vomiting	reflux		anemia	hypopara-thyroid
Complications of hypoglycemia	car accident, LOC	car accident	Hand callous/inability to monitor glucose	seizures	severe headaches	seizures	n/a
Nadir glucose with OGTT (mg/dL)	44	44	38	60	46	54	64	50 ± 9.5
HOMA-IR at diagnosis (from OGTT)	2.08	0.85	0.61	1.58	1.12	1.54	0.92	1.2 ± 0.5
Hemoglobin A1C at diagnosis	5.70%	5.50%	5.50%	5.60%	5.00%	5.60%	n/a	5.48 ± 0.2%
Treatment modalities implemented prior to reversal	Dietary, acarbose, verapamil	Dietary, acarbose, diazoxide, verapamil, octreotide	Dietary, acarbose, diazoxide	Dietary, acarbose	Dietary, acarbose, prednisone	Dietary, acarbose	n/a
BMI at reversal (kg/m2)	27.5	24	33	28	30	23	28	27 ± 3.5
Reversal surgery date (months post bypass)	39	41	48	93	122	55	33	62 ± 33
Reversal anatomy	normal	sleeve gastrectomy	sleeve gastrectomy	sleeve gastrectomy	sleeve gastrectomy	normal	normal
Weight change from G-tube MTT to post op MTT (lbs/BMI in kg/m2)	21 lbs +3.2 BMI	−21 lbs −3.9 BMI	28 lbs +3.2 BMI	0 lbs	−22 lbs −3.5 BMI	17 lbs +3.1 BMI	−14 lbs −2.4 BMI	2 ± 19 lbs 0 ± 3.2 BMI
Total weight change with reversal (lbs/BMI in kg/m2)	38 lbs +5.8 BMI	11 lbs +2 BMI	128 lbs +16.4 BMI	37 lbs +5.1 BMI	2 lbs +0.3 BMI	19 lbs +3.5 BMI	13 lbs +2.2 BMI	35 ± 43 lbs 5 ± 5.3 BMI
BMI at last follow up after reversal (kg/m2)	33.3	26.3	49.2	33	30.3	26.2	30	33 ± 8
Months of followup after reversal	47	18	34	20	9	3	11	20 ± 15