Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Mar 27;8:4947. doi: 10.1038/s41598-018-23062-6

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

An interstitial space is found in the dermis and submucosae and other fibroconnective tissues throughout the body. (A) Skin stained with H&E (upper left 10×, upper right 40×) shows the same structures as identified in the extrahepatic bile duct. Immunostain for CD34 (lower left, brown DAB, light blue hematoxylin counterstain, 40×) highlights that the lining cells are intermittent and often on one side of the collagen bundles, but not the other. pCLE applied to the skin in vivo following this histologic observation confirms that the histologic appearance predicts the in vivo reticular pattern when pCLE is applied to the skin. (B) Schematic showing location of identical histologic structures seen in fibroconnective tissues throughout the body (see Supplemental Fig. 1 for histology images). Illustration by Jill Gregory. Printed with permission from Mount Sinai Health System, licenced under CC-BY-ND. (https://creativecommons.org/licenses/by-nd/4.0/legalcode).