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. 2018 Mar 27;8:5249. doi: 10.1038/s41598-018-23537-6

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Involvement of proteins found in the yolk sac fluid and the uterine fluid of pregnant mares in GO terms and pathways representing embryo-maternal interaction. All GO terms and pathways that include ‘embryo’, ‘maternal’ or ‘uterus’ in their description were selected, together with all identified proteins in either the yolk sac or uterine fluid of pregnant horses belonging to these GO terms or pathways. These GO terms, pathways and proteins were then visualized using Cytoscape 3.3.0. Proteins found only in the uterine fluid are represented as red circles, proteins found only in the yolk sac as yellow circles and proteins found in both as purple circles. Proteins significantly (FDR corrected p-value < 0.05) up- or downregulated in the uterine fluid of pregnant mares are respectively larger and smaller circles (size not scaled with magnitude of up- or downregulation). GO terms and pathways are represented as a blue ‘V’, with lines indicating whether a GO term or pathway is associated with a protein.