Table 1.

Number and genotype frequency of tested MWHDs and estimation of the mutation allele frequency

	Number of dogs				Genotype frequency (%)			Mutation allele frequency
	Total	Clear	Carrier	Homozygous	Clear	Carrier	Homozygous
Total	733	448	234	51	61.1	31.9	7.0	0.2
Australia	17	16	1	0	94.1	5.9	0	0.03
Europea	604	363	202	39	60.1	33.4	6.5	0.2
UK only	548	316	193	39	57.7	35.2	7.1	0.2
North-America	61	40	17	4	65.6	27.9	6.6	0.2

^aincluding UK

A total of 733 MWHDs were DNA tested in this study. Within the tested dogs 7.0% were homozygous for the NHLRC1 mutation and at risk for LD and 31.9% of the tested dogs carries the mutation. Similar frequencies were observed among the European population, including dogs of UK origin and in the dataset of dogs originating from UK only. Only small cohorts originated from Australia and North-America