Table 4.
Yearly number and genotype frequency of the tested MWHDs
| Genotype frequency (%) | ||||||
|---|---|---|---|---|---|---|
| Year | 2012 | 2013 | 2014 | 2015 | 2016 | 2017 |
| Clear | 70.6 | 48.1 | 61.6 | 68.8 | 65.1 | 71.6 |
| Carrier | 23.5 | 41.5 | 31.5 | 25.4 | 29.5 | 25.7 |
| Homozygous | 5.9 | 10.4 | 6.8 | 5.8 | 5.4 | 2.7 |
| Total no. of dogs | 34 | 212 | 146 | 138 | 129 | 74 |
LD DNA test was developed in 2012 and after initial validation of the test in a small cohort of MWHDs the test has been offered since 2013. After a few years of genetic testing a decrease in the frequency of homozygous and carrier dogs can be observed and as a consequence the frequency of clear dogs has increased over the years. The slow decrease indicates that carrier dogs are kept as part of the breeding program to avoid compromising the genetic diversity of MWHDs