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. 2017 Dec 12;61(6):625–635. doi: 10.1042/EBC20170092

Figure 1. Outcomes of ER stress.

Figure 1

Perturbation of ER homeostasis or ‘ER stress’ (blue), is ameliorated by the triggering of signalling cascades (yellow), which in turn engage downstream effector mechanisms (green). Generally speaking, these mechanisms restore homeostasis. This review will discuss these pathways and mechanisms, with particular focus on autophagy as a potential effector and, in further detail, selective autophagic degradation of ER luminal contents or ER (ER-quality control (ERQC)-autophagy, ER-associated degradation (ERAD)-II and ER-phagy).