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. 2017 Nov 8;61(5):505–516. doi: 10.1042/EBC20170041

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© 2017 The Author(s).

This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY).

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(A) Crystal structure of VHL:MZ1:Brd4^BD2 (PDB ID: 5T35). (B) Conformation of MZ1 when bound to the ternary complex. (C) Ternary (T) complex equilibria for protein A, protein B and PROTAC (P). (D) Simulation showing amount of ternary complex formation and its relationship with cooperativity. K_d^A and K_d^B are maintained constant for all three cases.