Table 4.

Multivariable risk prediction model of 1-year mortality and MACE in CLI patients including myocardial injury after endovascular revascularization (≥ 14 ng/L and ≥ 30% relative increase in hsTnT) and baseline cardiac biomarkers (hsTnT and NT-pro-BNP)

	1-year mortality		1-year MACE
	Adjusted hazard ratio (95% CI)	p value	Adjusted OR (95% CI)	p value
Age	0.99 (0.95–1.033)	0.653	0.99 (0.96–1.03)	0.715
Sex
Female	Reference		Reference
Male	0.71 (0.31–1.64)	0.426	0.84 (0.39–1.82)	0.658
Rutherford
4	Reference		Reference
5	1.52 (0.50–4.59)	0.461	1.259 (0.49–3.26)	0.634
6	1.037 (0.26–4.17)	0.959	0.888 (0.25–3.10)	0.853
CAD	1.64 (0.66–4.09)	0.288	1.37 (0.56–3.35)	0.492
History of MI	0.87 (0.33–2.269)	0.768	1.19 (0.47–3.04)	0.714
DM	0.89 (0.41–1.93)	0.773	1.19 (0.57–2.48)	0.639
CRP	1.005 (0.999–1.011)	0.087	1.004 (0.997–1.01)	0.296
eGFR	1.002 (0.991–1.014)	0.719	0.9997 (0.9882–1.011)	0.956
NT-proBNP	1.00004 (0.999–1.00009)	0.149	1.00005 (0.99998–1.00012)	0.152
TnT0	1.002 (0.994–1.01)	0.649	0.999 (0.987–1.011)	0.868
Myocardial injury: hsTnT ≥ 14 ng/L with ≥ 30% relative hsTnT increase	2.44 (1.18–5.06)	0.016	2.89 (1.41–5.92)	0.004

CRP, eGFR, TnT and NT-proBNP expressed in the model as continuous variables. Cox proportional hazard analysis for the 1-year mortality model [C-index = 0.677 (SE = 0.051)] with the corresponding adjusted hazard radio (aHR) and 95% confidence interval (CI); multivariable logistic regression for 1-year MACE model [AUC = 0.65] with the corresponding adjusted odds ratio and 95% CI

CAD coronary artery disease, CI confidence interval, CRP C-reactive protein, DM diabetes mellitus, eGFR estimated glomerular filtration rate, MACE major adverse cardiovascular events, MI myocardial infarction, NT-pro-BNP N-terminal brain natriuretic peptide, TnT troponin T