Table 4.
Multivariable risk prediction model of 1-year mortality and MACE in CLI patients including myocardial injury after endovascular revascularization (≥ 14 ng/L and ≥ 30% relative increase in hsTnT) and baseline cardiac biomarkers (hsTnT and NT-pro-BNP)
| 1-year mortality | 1-year MACE | |||
|---|---|---|---|---|
| Adjusted hazard ratio (95% CI) | p value | Adjusted OR (95% CI) | p value | |
| Age | 0.99 (0.95–1.033) | 0.653 | 0.99 (0.96–1.03) | 0.715 |
| Sex | ||||
| Female | Reference | Reference | ||
| Male | 0.71 (0.31–1.64) | 0.426 | 0.84 (0.39–1.82) | 0.658 |
| Rutherford | ||||
| 4 | Reference | Reference | ||
| 5 | 1.52 (0.50–4.59) | 0.461 | 1.259 (0.49–3.26) | 0.634 |
| 6 | 1.037 (0.26–4.17) | 0.959 | 0.888 (0.25–3.10) | 0.853 |
| CAD | 1.64 (0.66–4.09) | 0.288 | 1.37 (0.56–3.35) | 0.492 |
| History of MI | 0.87 (0.33–2.269) | 0.768 | 1.19 (0.47–3.04) | 0.714 |
| DM | 0.89 (0.41–1.93) | 0.773 | 1.19 (0.57–2.48) | 0.639 |
| CRP | 1.005 (0.999–1.011) | 0.087 | 1.004 (0.997–1.01) | 0.296 |
| eGFR | 1.002 (0.991–1.014) | 0.719 | 0.9997 (0.9882–1.011) | 0.956 |
| NT-proBNP | 1.00004 (0.999–1.00009) | 0.149 | 1.00005 (0.99998–1.00012) | 0.152 |
| TnT0 | 1.002 (0.994–1.01) | 0.649 | 0.999 (0.987–1.011) | 0.868 |
| Myocardial injury: hsTnT ≥ 14 ng/L with ≥ 30% relative hsTnT increase | 2.44 (1.18–5.06) | 0.016 | 2.89 (1.41–5.92) | 0.004 |
CRP, eGFR, TnT and NT-proBNP expressed in the model as continuous variables. Cox proportional hazard analysis for the 1-year mortality model [C-index = 0.677 (SE = 0.051)] with the corresponding adjusted hazard radio (aHR) and 95% confidence interval (CI); multivariable logistic regression for 1-year MACE model [AUC = 0.65] with the corresponding adjusted odds ratio and 95% CI
CAD coronary artery disease, CI confidence interval, CRP C-reactive protein, DM diabetes mellitus, eGFR estimated glomerular filtration rate, MACE major adverse cardiovascular events, MI myocardial infarction, NT-pro-BNP N-terminal brain natriuretic peptide, TnT troponin T