Fig. 1.

Overview of the model. Each area is modeled as the volume under $1{\mathrm{mm}}^2$ of cortical surface with area- and layer-specific population sizes. The local connectivity inside each area is based on the microcircuit model of Potjans and Diesmann (2014). Cortico-cortical connectivity is area- and layer-specific. It is derived from tracing data stored in the CoCoMac database (Stephan et al. 2001; Bakker et al. 2012), quantitative retrograde tracing data from Markov et al. (2014a, b) and reconstructed morphologies from Binzegger et al. (2004). Microcircuit diagrams adapted from Potjans and Diesmann (2014) (with permission). Large-scale network diagram adapted from Kunkel et al. (2009). The dendritic morphologies in the cortico-cortical connectivity illustration are extracted from Stepanyants et al. (2008) (inhibitory L4 cell) and Mainen and Sejnowski (1996) (L5 pyramidal cell), respectively (source: http://NeuroMorpho.org; Ascoli et al. 2007)