Table 2.

Cognitive Functioning Tests: LS Means (SE) Over Time

	Placebo (N=24)	Esketamine 84 mg (N=23/24)a	p valueb
Detectionc (Log10 ms)
40 minutesd	2.44 (0.014)	2.51 (0.014)	0.0011
2 hours	2.42 (0.011)	2.43 (0.011)	0.8217
4 hours	2.43 (0.011)	2.41 (0.011)	0.3802
6 hours	2.43 (0.013)	2.40 (0.013)	0.1358
Identificationc (Log10 ms)
40 minutes	2.64 (0.009)	2.68 (0.009)	0.0006
2 hours	2.63 (0.010)	2.63 (0.010)	0.7941
4 hours	2.63 (0.009)	2.62 (0.009)	0.2226
6 hours	2.63 (0.011)	2.60 (0.011)	0.1290
One-Card Learning (arcsine of proportion of correct responses)
40 minutes	1.09 (0.021)	0.99 (0.021)	0.0040
2 hours	1.11 (0.021)	1.07 (0.021)	0.1483
4 hours	1.12 (0.021)	1.10 (0.021)	0.4465
6 hours	1.15 (0.017)	1.15 (0.017)	0.7450
One Back Memoryc (Log10 ms)
40 minutes	2.75 (0.012)	2.80 (0.012)	0.0017
2 hours	2.74 (0.012)	2.76 (0.012)	0.1579
4 hours	2.73 (0.010)	2.74 (0.010)	0.3791
6 hours	2.72 (0.011)	2.72 (0.011)	0.9674
Groton Maze Learning Test (total numbers of errors)
40 minutes	38.5 (2.45)	59.7 (2.51)	<0.0001
2 hours	36.7 (2.26)	41.7 (2.31)	0.1250
4 hours	39.6 (2.17)	37.1 (2.17)	0.2986
6 hours	33.6 (1.79)	36.8 (1.79)	0.1422

Detection - speed of performance (Log10 ms), Identification - speed of performance (Log10 ms), One-Card learning - accuracy of performance, One Back memory - speed of performance (Log10 ms), Groton Maze learning test - total numbers of errors, ms - milliseconds

^aN=23 in esketamine groups for 40 minutes and 2 hours testing periods, N=24 for 4 and 6 hours testing periods

^bp values (2-sided with level of significance of 5%) are based on the mixed-effect model with baseline score as a covariate, and treatment, period, gender and sequence as fixed effects, and subject within sequence as a random effect

^cFor these timed tests, higher scores reflect poorer performance

^dAll times listed (40 minutes, 2, 4, and 6 hours) reflect the times following dosing at which the testing was performed