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. 2001 Sep 18;98(20):11152–11157. doi: 10.1073/pnas.191387498

Figure 1.

Figure 1

Physical map of a P. abyssi chromosomal segment (sequence coordinates 118,000–128,000) carrying the predicted replication origin (12). Locations of several restriction sites (H, HindIII; N, NheI; E, EcoRI; X, XbaI), probes used for N/N 2D analyses are indicated. Fragments A (4.9-kb NheI fragment), B (5.7-kb EcoRI fragment), C (4.1-kb HindIII fragment), and D (5.6-kb XbaI fragment) correspond to those analyzed in Fig. 2. The central third of the each fragment [a bubble detection zone (18)] is indicated by gray shading. A ≈1-kb boxed region upstream of, and partially overlapping with, the P. abyssi cdc6 indicates the region containing an active replication origin as demonstrated in Fig. 2.