Table 1.

Clustered distribution of GABA_B1, GIRK2 and Ca_V2.1 in active zones and dendritic shafts and spines

Molecule	Compartment	Real NND	Simulated NND	p value	Association (%)	N
GABAB1	Active zone	22.5 ± 5.6	35.8 ± 13.2	2.3E−04	78.9	19
	Dendrite	38.9 ± 17.4	83.2 ± 28.6	2.8E−10	96.0	25
	Spine	27.1 ± 16.5	44.9 ± 26.2	5.3E−19	89.0	91
GIRK2	Active zone	19.8 ± 5.2	48.7 ± 23.3	8.7E−05	89.5	19
	Dendrite	43.2 ± 29.2	204.8 ± 123.9	5.3E−06	100.0	24
	Spine	30.6 ± 22.2	80.6 ± 37.7	1.2E−24	83.0	88
CaV2.1	Active zone	20.0 ± 5.8	37.3 ± 24.4	3.9E−04	97.1	35
	Dendrite	36.9 ± 16.9	141.8 ± 102.6	2.4E−04	100.0	26
	Spine	27.6 ± 17.5	66.0 ± 33.5	1.5E−04	84.2	19

NNDs are reported as mean ± standard deviation of image means, in case of simulations, image means are the means over all 500 simulations of that image. p values were obtained by two-sided paired t test followed by Holm–Bonferroni correction. “Association” shows the percentage of image means within the lowest 2.5% of simulation means. In none of the images did we detect a significant dissociation, i.e. a mean NND within the highest 2.5% of simulated mean NNDs. N indicates the number of images used for analysis