Table 2.
Spatial relationship of GABAB1 with GIRK2 and CaV2.1
| Simulated molecule | Compartment | Real NND | Simulated NND | p value | Association (%) | Dissociation (%) | N |
|---|---|---|---|---|---|---|---|
| GIRK2 | Active zone | 42.4 ± 13.8 | 47.0 ± 18.4 | 0.36 | 5.3 | 5.3 | 19 |
| Dendrite | 158.4 ± 78.4 | 119.2 ± 48.8 | 0.0088 | 4.2 | 50.0 | 24 | |
| Spine | 42.4 ± 20.9 | 59.2 ± 22.5 | 4.1E−14 | 21.3 | 1.1 | 89 | |
| CaV2.1 | Active zone | 41.8 ± 11.6 | 43.1 ± 11.4 | 0.77 | 14.3 | 2.9 | 35 |
| Dendrite | 44.0 ± 17.8 | 62.9 ± 13.7 | 3.4E−08 | 46.2 | 0.0 | 26 | |
| Spine | 98.0 ± 37.7 | 96.5 ± 34.5 | 0.83 | 10.0 | 10.0 | 20 |
NNDs are reported as mean ± standard deviation of image means, in case of simulations, image means are the means over all 500 simulations of that image. p values were obtained by two-sided paired t test followed by Holm–Bonferroni correction. “Percent significant” show the percentage of images whose mean NNDs are within the top or bottom 2.5% of simulation means. “Dissociation” and “Association” show the percentage of image means within the top and bottom 2.5%, respectively, of simulation means. N indicates the number of images used for analysis