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. 2017 Nov 22;223(3):1537–1564. doi: 10.1007/s00429-017-1559-z

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© The Author(s) 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 8 — Reduction of oscillatory burst activity in the thalamus of TRIP8b^−/− mice. a Extracellular field potential recordings of burst activity in the VB complex evoked by stimulation of the IC. TRIP8b^−/− mice (n = 8 mice) show significantly lower numbers of evoked rhythmic bursts (Student’s t tests, *** indicates p < 0.001) compared to WT mice (n = 8 mice). b Image showing the position of recording (Re) and stimulation electrodes (Stm). c Bar graph comparing the mean number of bursts in VB complex of TRIP8b^−/− and WT mice in response to a single stimulus (Student’s t tests, *** indicates p < 0.001). d Bar graph comparing the total number of spikes during the burst activity between TRIP8b^−/− and WT mice (Student’s t tests, *** indicates p < 0.001). e Shorter duration of stimulus-induced burst activity in TRIP8b^−/− compared to WT mice (Student’s t tests, *** indicates p < 0.001). f and g Bath application of 0.5 µM ZD7288-induced time-dependent effects on intrathalamic network activity (Repeated-measures ANOVAs followed by Student’s t tests, n = 6 mice, *, **, *** indicate p < 0.05, p < 0.01, and p < 0.001, respectively. Each data point was compared to the value before ZD7288 application (no ZD7288))