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. 2018 Mar 20;9:140. doi: 10.3389/fphar.2018.00140

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Copyright © 2018 Khalid, Ullah, Khan, Afridi, Rasheed, Khan, Ali, Kim and Khan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of 3 days, oral honokiol treatment on GIT mucosa by H&E stained tissue sections (A) Normal GIT mucosa, (B) Piroxicam (10 mg/kg oral) GIT mucosa, (C) Honokiol (10 mg/kg oral) GIT mucosa. GIT mucosa were analyzed on day 3 post-treatment. Each section was presented at ×4, ×10, and ×20 original magnifications. In piroxicam multiple arrows indicate the location of distortion of superficial layer of gastric mucosa. Stomach showing desquamation of superficial layer of gastric mucosa. However, no such side effect is being observed in honokiol treated group.