FIGURE 4.
(A) Inhibition of CFA-induced thermal hyperalgesia at 0, 2, 4, and 6 time points due to trreatment of honokiol (10 mg/kg i.p.). (B) Chronic effect of honokiol on thermal hyperalgesia was measured every day after CFA injection from 0 to 6 days with an interval of day five in order to interpret the possible tolerance effect. The data are reported as the means (n = 5) ± SD, ∗P < 0.05, ∗∗P < 0.01, and ∗∗∗P < 0.001 indicate significant differences from the CFA-treated group. ###P < 0.001 indicates a significant difference from the control group.