Table 2.
Genes involved in the production of anti-Bd metabolites that are present on frog skin metagenomes.
| KEGG class | KEGG pathway | KO | Gene description | Anti-Bd metabolite |
|---|---|---|---|---|
| BSM | Prodigiosin biosynthesis | K00059 | fabG; 3-oxoacyl-[acyl-carrier protein] reductase | Prodigiosin |
| BSM | Prodigiosin biosynthesis | K00208 | fabI; enoyl-[acyl-carrier protein] reductase I | Prodigiosin |
| BSM | Prodigiosin biosynthesis | K00645 | fabD; [acyl-carrier-protein] S-malonyltransferase | Prodigiosin |
| MTP | Terpenoid backbone biosynthesis | K01641 | hydroxymethylglutaryl-CoA synthase | 2,4 DAPG |
| MTP | Geraniol degradation | K00022 | HADH; 3-hydroxyacyl-CoA dehydrogenase | I3C and tryptophol |
| MTP | Insect hormone biosynthesis | K00128 | ALDH; aldehyde dehydrogenase (NAD+) | I3C and tryptophol |
| AAM | Tryptophan metabolism | K00164 | 2-oxoglutarate dehydrogenase E1 component | I3C and tryptophol |
| BSM | Isoquinoline alkaloid biosynthesis | K00274 | MAO, aofH; monoamine oxidase | I3C and tryptophol |
| AAM | Tryptophan metabolism | K00452 | 3-hydroxyanthranilate 3,4-dioxygenase | I3C and tryptophol |
| AAM | Tryptophan metabolism | K00453 | tryptophan 2,3-dioxygenase | I3C and tryptophol |
| AAM | Tryptophan metabolism | K00466 | tryptophan 2-monooxygenase | I3C and tryptophol |
| AAM | Tryptophan metabolism | K01432 | arylformamidase | I3C and tryptophol |
| AAM | Tryptophan metabolism | K01556 | kynureninase | I3C and tryptophol |
| MTP | Limonene and pinene degradation | K01692 | paaF, echA; enoyl-CoA hydratase | I3C and tryptophol |
| AAM | Tryptophan metabolism | K10217 | aminomuconate-semialdehyde/2-hydroxymuconate-6-semialdehyde dehydrogenase | I3C and tryptophol |
| AAM | Tryptophan metabolism | K14338 | cypD_E, CYP102A2_3 | I3C and tryptophol |
The first column indicates broad functional classes: BSM, Biosynthesis of secondary metabolites; MTP, Metabolism of terpenoids and polyketides; AAM, Amino acid metabolism.