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. 2018 Mar 20;9:93. doi: 10.3389/fgene.2018.00093

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Copyright © 2018 Riad, Elhelw, Shawer, El-Ekiaby, Salah, Zekri, Esmat, Amleh and Abdelaziz.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Expression profile of CLDN1 and miR-182 in infected liver biopsies and Huh7 cells. No difference in CLDN1 mRNA expression is observed in liver biopsies of HCV patients (N = 17) compared to healthy controls (N = 10), while miR-182 (N = 17, p = 0.0211*) is downregulated in HCV-infected patients compared to healthy controls (N = 10). Higher expression of CLDN1 mRNA is observed in JFH1- (p < 0.0001***) and ED43/JFH1- (p = 0.0429*) infected compared to uninfected Huh7 cell lines. miR-182 shows higher expression levels in JFH1-infected Huh7 cells (p = 0.0156*) and reduced expression in ED43/JFH1-infected Huh7 cells (p = 0.0104*) compared to naïve Huh7 cells. Relative Quantitation (RQ) is used for expression of the results. ***p < 0.001, *p < 0.05 and ns, statistically not significant.