Table 2.
Causal genes and genetic risk factors for FTD
| Causal genes | Chromosome | Function |
| MAPT | 17 | Microtubule stabilization, assembly and cytoskeletal dynamics |
| GRN | 17 | Inflammation |
| C9ORF72 | 9 | Nucleocytoplasmic transport, autophagy, intercellular trafficking |
| CHMP2B | 3 | Autophagy, protein trafficking and degradation |
| VCP-1 | 9 | Autophagy, protein trafficking and degradation |
| SQSTM1 | 5 | Encodes for p62, autophagy, protein degradation |
| CHCHD10 | 22 | Mitochondrial protein |
| TBK1 | 12 | Autophagy, protein trafficking and degradation |
| TARDBP | 1 | Encodes for TDP-43, transcription factor |
| FUS | 16 | Encodes for FUS, transcription factor |
| UBQLN2 | X | Autophagy, protein trafficking and degradation |
| TUBA4A | 2 | Cytoskeletal dynamics |
| Risk Factors | ||
| TMEM106B | 11 | Transmembrane protein |
| GRN | 17 | Inflammation |
| RAB8/CTSC | 11 | Lysosomal biology and protein trafficking |
| HLA | 6 | Immune system |