Table 1.

Reported specificities of ACE catalytic domains and some licensed and experimental ACE-1 inhibitors

Inhibitor	N-domain specificity	C-domain specificity	N- &C- domain specificity	References
Captopril	++	NONE	+	[90, 91, 95, 96]
Lisinopril	NONE	++	+	[90, 91, 95, 96]
Lisinopril-tryptophan	NONE	+	NONE	[96–98]
Enalapril	++	NONE	+	[91, 95, 96]
Ramipril	NONE	NONE	+	[96]
*RXP407	++	NONE	NONE	[95, 96, 99]
*RXP380	NONE	++	NONE	[95, 96, 99]

Experimental compounds are highlighted by ^*. the degree of affinity is denoted by the number of +’s while NONE corresponds to no evidence of binding.