Table 4.

List of studies of blood-based protein biomarkers of CSF Aβ and tau

Reference	Cohorts	Markers	Methods	Results
Kiddle et al., [59]	ADNI cohort: 16 AD, 52 MCI and 3 controls	146 proteins probed	Human Discovery Multi-Analyte Profile (MAP) and Luminex	-Leptin was significantly associated with CSF Aβ1 - 42
Westwoodet al., [79]	METSIM study cohort: 58 cognitively healthy men including 30 insulin non-resistant and 28 insulin resistant subjects	FCN2, FGG, CFHR1 and ApoA1	FCN2, FGG and CFHR1 proteins were measured by ELISA, ApoA1 was measured by Luminex xMAP assay	-FCN2 was significantly negatively correlated with CSF Aβ

CSF, cerebrospinal fluid; AD, Alzheimer’s disease; ADNI, Alzheimer’s Disease Neuroimaging Initiative; METSIM, Metabolic Syndrome in Men; MCI, mild cognitive impairment; FCN2, ficolin-2; FGG, fibrinogen γ-chain; CFHR1, complement factor H-related 1; APO-A1, apolipoprotein A1; LC-MS/MS, Liquid chromatography tandem mass spectrometry; ELISA, enzyme-linked immunosorbent assay; FGB; fibrinogen β chain; ApoC-IV, apolipoprotein C-IV; PET, positron emission tomography; SMC, subjective memory complaints; MCIs, stable MCI patients; MCIc, MCI converting to AD.