Table 5.

Summarization of most reported biomarkers from our studies

Biomarkers	Reference number	Case controls studies	Biomarkers of brain atrophy and rate of cognitive decline	Biomarkers of brain amyloid burden	Biomarkers of CSF Aβ
clusterin	6	[36]	[33], [45], [41], [43], [44]	[41]
complement C3	6		[45], [41], [48], [59]	[56], [58], [59]
FGG	5		[41], [48]	[57], [59]	[79]
APOE	4	[36]	[44]	[59], [56]
PPY	3		[33], [59]	[59], [71]
α2M	3	[15]		[57], [58]
α-1-antitrypsin	3	[45]	[45], [44], [59]	[59]
FCN2	3		[33]		[79], Baird et al.,
					unpublished
TTR	3		[41], [44], [49]

α2M, α-2-macroglobulin; FGG, γ-fibrinogen; PPY, pancreatic polypeptide; FCN2, ficolin-2; TTR, transthyretin.