Table 1.

Redox proteomics identification of oxidatively or nitrosatively modified brain proteins from subjects with Alzheimer’s disease or amnestic mild cognitive impairment

Cellular Function or Pathway Dysfunction	Oxidatively or Nitrosatively Modified Brain Proteins
Glucose Metabolism	GRP-78; Alpha-enolase; Aldoase; TPI; GAPDH; PGM; Pyruvate Kinase; Lactate Dehydrogenase; Aconitase; Malate Dehydrogenase; Carbonic Anhydrase-2; ATP Synthase-alpha
Excitotoxicity	Glutamine Synthetase
Proteasome	HSP70; Ubiquitin C-terminal Hydrolase L-1
Antioxidant Defense	MnSOD; Peroxidredoxin 6; Carbonyl Reductase
Lipid and Cholinergic Function	Neuropolypeptide h3; GST; MRP-1
Synaptic Plasticity	DRP-2 (CRMP-2); Beta-Actin; Alpha-Tubulin; Gamma-SNAP; Syntaxin Binding Protein-1; Fascin-1
Tau Hyperphosphorylation, Aβ Production; Cell Cycle	Pin 1
Mitochondria	VDAC-1
Cell Signaling; Regulation of Antioxidant Proteins; Apoptosis	14-3-3-Gamma; MAPK-1; p53
Protein Synthesis	Initiation Factor-alpha; Elongation Factor-Tu