Fig.2.

Components of the pathology due to SSVD. A, B) Low power (A) and higher power (B) views of a histological section from a case of SSVD. The section has been stained for myelin (blue) (Luxol fast blue/cresyl violet stain). There is diffuse pallor of staining and, at the top left corner of the section in (A), the tissue is necrotic. B) Damaged white matter at higher power. The nuclei (purple) are chiefly those of infiltrating macrophages. C) Greatly dilated perivascular space (hematoxylin and eosin stain). D) Small artery with a grossly thickened wall in which collagen has replaced smooth muscle (hematoxylin and eosin stain). E) Normal white matter arterioles in which the deeper pink cells are smooth muscle cells. F) Severely fibrotic and stenosed arteriole from a case of SSVD (E and F, hematoxylin and eosin).