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Knockdown of CDKL3 blocks cell cycle progression at G1 phase and induces apoptosis in CCA cells. (A) RBE cells transfected with shCDKL3 showed increased percentage of cell population in G0/G1 phase; (B) Knockdown of CDKL3 in RBE cells led to a significant increase in apoptosis as compared to the cells without CDKL3 knockdown (12.02% vs. 4.73%, P < 0.01). The data represent mean ± SD. *P < 0.05, **P < 0.01, as compared with shCtrl.
