Table 3.

Mean, Median, and Standard Deviation, and Minimum and Maximum Plasma Concentrations of CBD, THC, THC-COOH, and OH-THC at Baseline, Across 10 Weeks of CBD Treatment, and After a ≥12-H Washout at Post-Treatment

	BL	w1	w2	w3	w4	w5	w6	w7	w8	w9	w10	PT
CBD (ng/mL)
Mean	0.1	5.8	10.4	10.7	18.4	19.4	19.7	23.6	11.6	19.4	26.0	7.8
Median	0.1	0.1	8.9	9.7	9.9	12.2	11.2	17.1	8.1	13.0	7.5	5.1
SD	0.1	8.6	8.7	5.3	18.3	19.8	20.9	17.4	8.1	21.1	41.6	7.4
Min	0.0	0.0	0.2	1.9	2.6	3.0	1.4	6.6	3.4	1.5	3.2	1.2
Max	0.3	27.9	36.6	21.4	65.8	59.8	76.5	65.3	32.7	70.8	129.5	31.0
THC (ng/mL)
Mean	5.9	5.4	8.7	6.0	6.7	9.2	10.0	8.9	9.9	10.3	8.4	7.4
Median	1.9	1.4	3.6	2.0	2.5	4.5	2.4	1.7	3.6	2.3	6.2	2.7
SD	9.8	7.2	14.6	7.9	8.1	15.3	15.0	14.9	15.2	16.2	9.3	8.5
Min	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Max	37.2	21.4	62.3	26.2	26.2	63.3	56.9	46.2	58.0	56.8	30.5	26.5
OH-THC (ng/mL)
Mean	2.0	2.7	2.4	2.7	3.1	3.3	4.3	3.1	5.3	4.0	4.5	3.2
Median	0.9	1.0	1.5	0.9	1.4	1.7	1.3	1.2	1.6	1.6	2.2	1.3
SD	3.3	3.5	2.7	4.1	3.5	4.9	6.0	4.4	8.6	5.2	6.0	3.9
Min	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Max	13.4	11.8	8.8	17.5	10.1	16.9	17.5	15.7	27.8	15.1	18.0	12.4
COOH-THC (ng/mL)
Mean	44.7	48.8	46.7	52.8	54.2	52.5	69.5	61.0	80.2	76.1	95.5	67.4
Median	18.9	28.7	27.2	23.4	30.8	32.7	28.8	21.2	27.6	26.6	61.6	25.3
SD	75.5	63.2	50.5	82.1	61.5	56.2	96.2	80.9	113.2	85.3	107.1	77.7
Min	0.2	0.5	0.6	0.2	0.2	0.2	0.1	0.5	0.3	0.5	0.1	0.2
Max	315.5	199.1	155.0	352.8	196.9	158.4	358.0	227.4	454.8	203.1	289.7	251.4

BL, baseline; CBD, cannabidiol; Max, maximum; Min, minimum; PT, post-treatment; THC, Δ⁹-tetrahydrocannabinol; w1–w10, week 1–week 10.