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. 2018 Jan 31;9:98–113. doi: 10.1016/j.molmet.2018.01.009

Figure 2.

Figure 2

Endothelium-dependent relaxation in mesenteric arterioles. (A) Urine albumin levels (i) and urine albumin-to-creatinine ratio (UACR) (ii) were determined in 6 month-old Cc1+/+ (white), Cc1−/− (black) and Cc1−/−xliver+ mice (gray) (n = 6–7/genotype). Values are expressed as mean ± SEM. (B) Nitric oxide (NO) release was determined in phenylephrine (PE)-pre-contracted arterioles (i), following stimulation with acetylcholine (Ach) (ii) and sodium nitroprusside (SNP) (iii) from 8 to 9 month-old mice (n = 5–6/genotype). Values are expressed as mean ± SEM. *P ≤ 0.05 versus Cc1+/+ and †P ≤ 0.05 versus Cc1−/−. (C) Plasma NO, (D) plasma endothelin-1 (Et-1) and (E) aortic NO levels were assayed in triplicate in n ≥ 5 mice/genotype (7-to-8 months of age). Values are expressed as mean ± SEM. In A–E, *P ≤ 0.05 versus Cc1+/+, †P ≤ 0.05 Cc1−/−xliver+ versus Cc1−/−.