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. 2018 Jan 11;9:131–140. doi: 10.1016/j.molmet.2018.01.005

Figure 4.

Figure 4

INT-767 promotes regression of diet-induced hyperlipidemia and atherosclerosis in Apoe−/−mice. Male Apoe−/− mice were fed a Western diet (42% fat/0.2 cholesterol) for 7 weeks, and then gavaged with either vehicle or INT-767 (30 mg/kg, once a day) for 6 weeks (n = 8 per group). (A) Body weight. (B) Body fat content at baseline, before, or after gavage with INT-767. (C) Plasma TG levels. (D) Plasma total cholesterol levels. (E) Circulating cholesterol lipoprotein distribution. Chol, cholesterol. (F) Circulating TG lipoprotein distribution. (G) Representative en face aortas stained with Oil Red O (ORO). (H) Average lesion size of en face aortas. (I) Representative aortic root sections stained with ORO (left top panel) or picrosirius red (left middle panel), or immunostained for detection of MCP-1 (left bottom panel), F4/80 (right top panel), VCAM-1 (right middle panel) or 4-HNE (right bottom panel). (J) Quantification of average staining areas per section shown in (I). *P < 0.05, **P < 0.01.