Figure 5.

INT-767 promotes regression of NAFLD in Apoe^−/−mice. Male Apoe^−/− mice have been described in the legend of Figure 4 (n = 8 per group). (A) Hepatic total cholesterol levels. (B) Hepatic TG levels. (C) Representative liver section images stained by Oil Red O. (D) Hepatic mRNA levels. (E and F) Hepatic proteins were detected by immunoblots (E) and then quantified (F). (G) Detection of apoptotic cells by TUNEL assays. (H) Quantification of apoptotic cells (%). (I) Hepatic MDA levels. (J) Liver sections were immunostained for detection of F4/80. (K) Representative liver images stained by Picrosirius red. (L) Hepatic hydroxyproline levels. Arrows point to staining-positive cells (G, J) or fibrosis (K). *P < 0.05, **P < 0.01.