Figure 5.
SIN activated Nrf2 pathway in rat lung tissues. (A) Protein level of Nrf2, HO-1, and NQO-1 in the lung tissues of rats from different groups was measured by Western blot assay; (B–D) relative Nrf2, HO-1, and NQO-1 mRNA level in the lung tissues of rats from different groups was measured by qRT-PCR. Con – Control group (rats exposed to normoxia); Con-S – rats with normoxia exposure + sinomenine administration 41 μg kg−1∙min−1 for 25 days; CIH – rats exposed to CIH alone; CIH-S – rats with CIH exposure + sinomenine administration at 41 μg kg−1∙min−1 for 25 days. Data are reported as means ±SE. ** p<0.01 vs. control; # p<0.05 vs. CIH.