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. 2018 Feb 3;9:28–42. doi: 10.1016/j.molmet.2018.01.017

Figure 6.

Figure 6

Global gene expression analysis identified classical browning and thermogenic pathways regulated by AM73 and AM80. RNA from brown adipocytes treated with 10 μM AM73 or AM80 for 8 h was used for global gene expression analysis by microarray. All data were normalized for a negative control (DMSO). Distribution of genes affected by AM73 or AM80 treatment shown as heat map (A), Volcano plots (B–C) and overlapping genes (D). Biological, molecular and KEGG pathways affected by AM73 (E), AM80 (F), or both (G). The gene regulatory regions for genes affected by either treatment was analyzed by DiRE (distant regulatory regions of co-regulated genes) to identify putative factors regulating the gene expression changes, H–I.