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. 2018 Feb 3;9:28–42. doi: 10.1016/j.molmet.2018.01.017

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© 2018 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Comparison of global gene expression changes following cAMP or AM73 treatment of murine brown adipocytes. RNA from brown adipocytes treated with 10 μM AM73 for 8 h was used for global gene expression analysis by microarray. Gene lists for AM73-treated brown adipocytes was compared to previously published results from the same cell line treated with cAMP for 4 h. Overlap of hits between cAMP 4 h versus AM73 (A). Top right panel of A shows Gene Ontology (GO) pathways significantly changed by AM73 alone (excluding genes shared with cAMP). The lower panel shows pathways changed by both cAMP and AM73; both up (upper right) or both down (lower left); or in opposite direction; up with cAMP 4 h and down with AM73 (upper left) or down with cAMP 4 h and up with AM73/AM80 (lower right). (B) Gene lists for the AM73-regulated pathways brown fat cell differentiation and oxidation reduction.