Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Dissociation constants of adenosine receptor agonists for binding to sites present in NEM-preteated cardiac membranes estimated by inhibition of [3H]CPXa binding
| Compound | K1, nM (% total) |
K2, nM (% total) |
|---|---|---|
| R-PIA | 5 ± 3 (84%) | 152 ± 96 (16%) |
| IABA | 25 ± 4 (100%) | – |
| NECA | 89 ± 44 (30%) | 4016 ± 398 (70%) |
| NCCA | 110 ± 66 (24%) | 4049 ± 354 (76%) |
The Kd for [3H]CPX was 0.12 ± 0.01 nM (Bmax 100 ± 8 fmol/mg; N = 3). 0.6 nM [3H]CPX was used in the inhibition experiments
