Table 1. IC50 values (μM) of Ru1, dppz, cisplatin or [Ru(phen)2(dppz)]2+ towards OE21 human oesophageal squamous cell carcinoma, OE33 and FLO-1 human oesophageal adenocarcinoma cancer and hSAEC1-KT normal human small airway epithelial cells a .
| OE21 |
OE33 |
FLO1 |
hSAEC1-KT |
|||||
| 24 h | 72 h | 24 h | 72 h | 24 h | 72 h | 24 h | 72 h | |
| Ru1 | 21 ± 4.2 | 2.9 ± 1.5 | 44.5 ± 3.5 | 27 ± 2.8 | 42 ± 8 | 11.5 ± 2.1 | 78.5 ± 1.3 | 22 ± 2 |
| dppz | 6.5 ± 2.1 | 3.3 ± 0.4 | 6.6 ± 2 | 5.7 ± 0.9 | 7.5 ± 0.8 | 1.9 ± 1.1 | >10 | >10 |
| Cisplatin | 22.6 ± 3.6 | 6.3 ± 0.6 | 11 ± 1.4 | 3.25 ± 1 | 26.5 ± 0.7 | 4.7 ± 0.7 | 21.5 ± 5 | 15.8 ± 2 |
| [Ru(phen)2(dppz)]2+ | >100 | >100 | >100 | >100 | >100 | 34.0 ± 5.7 | N.D. | N.D. |
aDetermined by MTT assay (24 or 72 h constant exposure). Data mean of two independent experiments ± S.D. N.D. = not done.