Table 2. IC₅₀ values for compounds 2b, 3b and cisplatin (CDDP) towards human ovarian cancer cells and normal human fibroblast cells.

Compound	IC50 a (μM)		RF b	IC50 a (μM) MRC-5	SF c
	A2780	A2780cisR
2b	3.5 ± 0.94	2.3 ± 0.7	0.66	7.28 ± 0.39	2.1
3b	0.53 ± 0.01	0.30 ± 0.03	0.57	8.54 ± 0.32	16.1
CDDP d	1.2 ± 0.20	11.5 ± 0.3	9.6	16.2 ± 0.6	8.5

^aMeasured after 72 h of culture (mean of three independent experiments ± SD).

^bRF, resistance factor: IC₅₀ toward A2780cisR/IC₅₀ toward A2780 ratio.

^cSF, selectivity factor: IC₅₀ toward MRC-5/IC₅₀ for A2780 ratio.

^dValues taken from ref. 55.