Table 7.
Studies reporting the association of Trp64Arg (rs4994) with obesity and obesity-related disorders in different populations
| Population | Study showed rs4994: | References |
|---|---|---|
| Asians | Association with T2DM (meta-analysis) | [26] |
| Non-Asians | No association | |
| Asians | Association with BMI (meta-analysis) | 40 |
| African American | No association with BMI | 52 |
| S. African women | No association with MS | 41 |
| Brazilians/Caucasians | Combined effect in the modulation of OW/obesity and HDL-C in T2DM | 31 |
| Balinese | Association with obesity in rural females only | 38 |
| Caucasians | Association with elevated BMI and BMD | 48 |
| Chile (Ayara natives) | No association with BMI | 50 |
| Chinese | Association with HT and dyslipidaemias (metaanalysis) | 27 |
| Hungarian children | Association with increase body weight and BMI | 28 |
| S. Italians | Insulin resistance in males only | 46 |
| Japanese | Association with increase BMI | 51 |
| No association with BMI | 49 | |
| No relation with MS | 45 | |
| Japanese children | Association with increases visceral fat, blood pressure, triglycerides and reduced TAG | 32 |
| Japanese men | Association with annual weight gain | 35 |
| Kashmiris | Association with increase BMI, W/H ratio, dyslipidaemias, uncontrolled T2DM | 53 |
| Kyrgy | Association with increase obesity, abdominal obesity, decreased HDL | 37 |
| Mexican | Association with increase T2DM and MS | 39, 29 |
| Russians | Association with increase fat, glucose level, and uric acid | 33 |
| S. Spain | Association with T2DM | 44 |
| Taiwanese | No association with obesity | 36 |
| Saudis | Obesity, hyperlipidaemias, hyperinsulinaemia, hyperleptinaemia. | This study |