Table 3.

Univariate and multivariate analysis of variables correlated with metastasis-free survival

Variable	Univariate	Multivariate
	P-value	HR (95% CI)	P-value
Age	0.007		0.027
≤ 40 vs. > 40,< 65		3.936(1.291–11.998)	0.016
> =65 vs. > 40,< 65		1.900(0.947–3.815)	0.071
Menopausal status	0.779
Premenopausal vs. Postmenopausal
Breast surgery	0.433
Lumpectomy vs. Mastectomy
PT	0.000
T2 vs. T1		1.118(0.531–2.354)	0.769
T3 vs. T1		16.599(3.864–71.637)	0.000
PN	0.001	3.512(1.707–7.225)	0.001
N1 vs. N0
histologic subtype	0.648
Ductal vs. Lobular/orther
Grade	0.079
3 vs. 1–2
Ki67	0.033	2.079(1.056–4.093)	0.034
≥ 20% vs. < 20%
Hormone receptor expression	0.060
ER(+) PR(−)/ER(−) PR(+) vs. ER(+) PR(+)
Adjuvant CT	0.379
Yes vs. No
Adjuvant ET	0.615
Yes vs. No
Adjuvant RT	0.015	1.092(0.481–2.479)	0.834
Yes vs. No
TOP2A	0.023	2.414(1.228–4.746)	0.011
High vs. Low

HR Indicates hazard ratio, CI Confidence interval

Abbreviations: PT Pathologic T stage, PN Pathologic N stage

CT Chemotherapy, ET Endocrine therapy, RT Radiation