Table 1.

The identified protein in the hippocampus of DIO and DR rat.

Spot No.	Identified Protein	Relative value of the protein expression				Gi accession
		CON	MOD	DIO	DR
1	leukemia-associated phosphoprotein p18	779.9	649.9	78.5 ab	13.9 ab	134974
2	protein canopy homolog 2	3128.2	987.2 a	373.9 a	13.9 ab	117606182
3	heterogeneous nuclear ribonucleoprotein K	204.7	319.4	9.9 ab	225.5	48429097
4	neurocalcin-delta	1653	1178.4	573 a	128.9 ab	81909955
5	neuron-specific calcium-binding protein hippocalcin	4016.7	4892.9	1997.7	640.1 ab	8850221
6	Tubulin beta-2A chain	5293.1	5797.1	5440.8	1332.1 abc	144587401
7	ubiquinol-cytochrome c reductase	167.4	259.8	1834.4 ab	406.5 a	149045287
8	ubiquitin carboxyl-terminal hydrolase isozyme L1	8.4	399.3 a	31.3 b	67.9	68844977
9	dihydropyrimidinase-related protein 2	1161.7	1298.3	2997.1	3650.5 ab	1351260
10	dismutase	2038.7	1674.3	1002.8 a	204 a	818029
11	malate dehydrogenase	1646.8	614.5 a	3253.4 b	1639.5	81861572
12	beta-actin	4753.3	3317.1	139.9 ab	242.3 ab	46397316
13	gamma-actin	2580.6	3649.9	272.5 b	10864.9 a b	54036665
14	tubulin alpha-1B chain	1509.4	2470.1	4896.3	2293.1c	55976173
15	serum albumin precursor	684.7	951.9	1233.8 a	6561.9 abc	158138568

All listed substrates were identified by 2-DE and MALDI-TOF-MS analyses. SWISS-PROT and NCBI protein database were used to evaluate MS data. Relative value was significantly different from those of the CON group:

^ap<0.05; Relative value were significantly different from those of the MOD group:

^bp<0.05; Relative value were significantly different from those of the DIO group:

^cp<0.05; CON, control; MOD, model rats with learning and memory impairment; DIO, diet-induced obese; DR, diet-resistant; NCALD, Neurocalcin-delta.