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. 2018 Mar 20;9:562. doi: 10.3389/fimmu.2018.00562

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Copyright © 2018 Malik, Gupta, Mani, Gogoi and Bhatnagar.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Serum antiprotective antigen (PA) total IgG endpoint titer. Female Balb/c mice (6–8 weeks of age; n = 21) were immunized with 1× PBS, PA, trimethyl-chitosan (TMC) NP-PA, Poly IC PA, Poly I:C TMC NP-PA, CpG PA, and CpG TMC NP-PA via three routes: subcutaneous (SC), intramuscular (IM), and intraperitoneal (IP) with a prime dose and two booster doses with an interval of 7 and 15 days, respectively. The mice were bled on 28th and 42nd day and sera samples were collected from all mice. Serial dilutions of sera from each group were analyzed for anti-PA total IgG titer for (A) SC route, (B) IM route, and (C) IP route. Statistically significant differences between the groups are highlighted (* for P-value <0.05, ** for P-values <0.01, *** for P-values <0.001 and **** for P-values <0.0001).