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. 2018 Mar 27;37:69. doi: 10.1186/s13046-018-0740-4

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Knockdown of YAP inhibits pancreatic cancer cell invasion through inhibiting EMT a Transwell chamber assays of BxPC-3 and Panc-1 cells. The pretreated cells were seeded into a Matrigel-coated invasion chamber for an additional 48 h. b The invasive cells were quantified by counting the number of cells in 10 random fields at 100 × magnification. c & e Western blot assays were performed to evaluate the effect of YAP-shRNA on the protein expression of E-cadherin, N-cadherin, Vimentin and YAP in BxPC-3 and Panc-1 cells. d & f Real-time PCR was performed to evaluate the effect of YAP-shRNA on the mRNA expression of E-cadherin, N-cadherin and Vimentin. All of the data are presented as the mean ± SD of three independent experiments. Column: mean; bar: SD; *P < 0.05; **P < 0.01