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. 2018 Mar 2;7(3):17. doi: 10.3390/cells7030017

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Multiple ways of recruiting KMT2s complexes to chromatin. KMT2 complex recruitment includes direct and indirect DNA interactions, possibly by more than one of these occurring cooperatively: (1) AT-rich regions recognized by AT-hooks; (2) un-methylated CpG islands by CXXC domains; (3) DNA structures by AT-hooks and HMG-I domains; (4) nucleosomes by WDR5 that interacts with the histone H3 N-terminal region; (5) nucleosomes with distinct histone marks by PHD fingers; (6) through binding to sequence specific transcription factors (sTF); (7) recruited by co-factors that bind to sTFs; (8) through long noncoding RNAs; (9) through interaction with basal transcription factors (bTF); (10) indirectly through binding to RNA polymerase II (RNAP II).