Figure 1.

A schematic illustration of the new findings on Miro activity discussed in the text. Miro (splice isoforms not specified) could be localized to both mitochondria and peroxisomes to mediate microtubule-based transport by engaging the kinesin adaptors Trak1/2. Miro could also engage the actin motor Myo19 for actin-based mitochondrial transport. In neuronal cells, a switch from long-range Miro-mediated microtubule-based transport along axons and dendritic shafts to short-range actin-based transport in dendritic spines and growth cones may be conceivable, as illustrated speculatively by the dotted arrow.