Table 3.
ART cycle stimulation parameters and embryology outcomes
| Variable | Study group (n = 76) | Control group (n = 93) | p- value |
|---|---|---|---|
| Cycle stimulation | |||
| Total dose of Gn (IU), median (IQR) | 2000 (1200, 4275) | 3075 (1900, 4275) | 0.03 |
| Duration of stimulation (days), median (IQR) | 10 (9, 11) | 11 (9, 12) | 0.08 |
| Peak E2 concentration (pmol/l), median (IQR) | 2349 (892, 4784) | 1685 (1125, 3042) | 0.02 |
| Endometrial thickness on the day of hCG trigger (mm), mean ± SD | 10.12 ± 1.93 | 10.34 ± 1.50 | 0.13 |
| Patients who had oocyte retrieval | 72/76 (94.74) | 83/93 (89.25) | 0.82 |
| Cancelled cycles a, n (%) | 4/76 (5.23) | 10/93 (10.75) | 0.27 |
| Embryology outcomes | |||
| Retrieved oocytes, median (IQR) | 4 (2, 5) | 2 (1, 4) | 0.002 |
| ICSI cycles, n (%) | 24/76 (31.58) | 19/93 (20.43) | 0.20 |
| Fertilized oocytes (2PN), median (IQR) | 0.80 (0.50, 0.93) | 0.50 (0.33, 1.0) | 0.01 |
| Fertilization rate b, n (%) | 191/253 (67.49) | 191/283 (45.06) | 0.001 |
| Number of high quality embryos, median (IQR) | 1 (0, 2) | 0 (0, 1.75) | 0.03 |
aIncluded women in who did not respond to stimulation and did not have oocyte retrieval
bCalculated as following: the number of total 2PN embryos divided by the number of total inseminated oocytes
E2 – estradiol; Gn – gonadotrophin; hCG – human chorionic gonadotrophin; IQR – interquartile range; LH - luteinizing hormone; P - progesterone, 2PN – two pronuclear, SD - standard deviation