Table 3.
Commonly reported pharmacogenomics biomarkers
| Drug (s) | Therapeutic area | Biomarker |
|---|---|---|
| Abacavir | Infectious Disease (anti-retroviral therapy) | HLA-B |
| Amitriptyline, Clozapine | Psychiatry | CYP2D6 |
| Antidepressants | Depression | CYP2D6 |
| Azathioprine | Rheumatology | TMPT |
| Artemether | Infectious disease (malaria) | CYP2C8; CYP3A4; CYP3A5; CYP2B6 |
| Carbamazepine | Neurology | HLA-B |
| Carvedilol | Cardiology | CYP2D6 |
| Celecoxib | Rheumatology | CYP2C9 |
| Citalopram | Psychiatry | CYP2C19; CYP2D6 |
| Chloroquine (plus Quinine, Quinidine) | Infectious disease (malaria) | G6PD; CYP2D6 |
| Clopidogrel | Cardiology | CYP2C19 |
| Clozapine | Psychiatry | CYP2D6 |
| Codeine | Anesthesiology | CYP2D6 |
| Efavirenz | Infectious disease (antiretroviral therapy) | CYP2B6; CYP1A2; CYP2A6; UGT; CYP3A4 |
| Irinotecan | Oncology | UGT1A1 |
| Isoniazid | Infectious Disease | NAT2 |
| Metoprolol | Cardiology | CYP2D6 |
| Rifampicin | Infectious disease (Anti-TB) | CYP3A4 |
| Pravastatin, Simvastatin, Rosuvastatin | Endocrinology | LDL-R; SLCO1B1; APOE; PCSK9 |
| Taclolimus | Organ transplantation | CYP3A5 |
| Tamoxifen | Oncology | ESR1; CYP2D6 |
| Thioguanide, Azathioprine | Oncology | TMPT |
| Tramadol | Analgesic | CYP2D6 |
| Warfarin (Coumadin) | Cardiology or Hematology | CYP2C9; VKORC1 |