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. 2018 Mar 27;18:330. doi: 10.1186/s12885-018-4250-8

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 9 — Mechanism of anti-cancer effect from D5D knockdown, DGLA supplementation along with 5-FU in 4 T1 cells. a Western blot of procaspase 9, PARP, cleaved PARP, acetyl histone H3, and γH2AX from D5D-KD 4 T1 cells treated with 5-FU (50 μM), DGLA (100 μM) and 5-FU + DGLA at 48 h. Protein expression rate was normalized using β-actin as a loading control; and b Western blot of MMP-2, MMP-9, E-cadherin, vimentin and snail from D5D-KD 4 T1 cells treated with 5-FU (50 μM), DGLA (100 μM) and 5-FU + DGLA at 48 h. Protein expression rate was normalized using β-actin as a loading control. Data represent as mean ± standard deviation (*: significant difference vs. control with p < 0.05; and #: significant difference vs. 5-FU group with p < 0.05 from n ≥ 3)