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. 2018 Mar 27;16:30. doi: 10.1186/s12951-018-0350-5

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Relaxivity measurements and cell metal content determination of Mn-IOSP NCs: a the longitudinal relaxivity and transverse relaxivity of Mn-IOSP NCs at different pH (5.0, 6.5, 7.4), plots for 1/T₁ and 1/T₂ vs. Mn concentration, b iron and manganese content in A549 cells due to the uptake of NCs which modified with PAA-cRGD or PAA, c iron and manganese content in A549 cells due to the uptake of Mn-IOSPs in different concentrations, d T₁- and T₂-weighted MRI for A549 cells incubated with Mn-IOSP NCs at different concentrations, e in vivo T₁- and T₂-weighted MRI acquired before and after i.v. injection of Mn-IOSP NCs, the tumor sites were circled roughly with white dotted lines